New research shows that people with a higher blood DHA level are 49% less likely to develop Alzheimer’s disease vs. those with lower levels, according to the Fatty Acid Research Institute (FARI). The study, led by Aleix Sala-Vila, PhD, suggested that providing extra dietary omega-3 DHA, especially for those carrying the ApoE4 gene (which approximately doubles an individual’s susceptibility to develop AD) might slow the development of the disease. Such a cost-effective, low-risk dietary intervention like this could potentially save billions in health care costs.
In this prospective observational study conducted within the Framingham Offspring Cohort — including 1490 dementia-free participants aged =65 years old — researchers examined the association of red blood cell (RBC) docosahexaenoic acid (DHA) with incident Alzheimer’s Disease (AD), while also testing for an interaction with APOE-e4 carriership.
Risk for incident AD in the highest RBC DHA quintile (Q5, >6.1%) was 49% lower compared with the lowest quintile (Q1,